Characteristic Features of Breast Cancer in Women Aged ≤30 Years
JH Lee, CM Kuzmiak, E Cho, YM Park
Hong Kong J Radiol 2019;22:114-22
https://doi.org/10.12809/hkjr1916879
Objective: To identify and describe the imaging, clinicopathological and biological characteristics of breast cancer for women aged ≤30 years and to correlate the imaging features with clinical and molecular prognostic factors of breast cancer.
Methods: A total of 47 women aged ≤30 years with diagnosed breast cancer were included in this study. The patients’ clinic visit, radiology, and pathology reports were retrospectively reviewed. We analysed the associations between features and outcomes using Fisher’s exact test.
Results: The most common ultrasonographic feature was a mass with suspicious features for malignancy, which was assessed as Breast Imaging-Reporting and Data System (BI-RADS) category 4 (82.2%, 37 / 45) or
5 (17.8%, 8 / 45) in all cases. Of the invasive tumours, 69.0% (29 / 42) had a high histological grade, 61.4%
(27 / 44) were oestrogen receptor–positive, 56.8% (25 / 44) were progesterone receptor–positive, and 25.6%
(11 / 43) were human epidermal growth factor receptor type 2–positive. There was a significant correlation between mammographic mass margin and BRCA mutation (p = 0.0217); ultrasonographic mass features including margin, echo pattern, posterior feature and hormone receptor status (p = 0.0117-0.0467); and BI-RADS assessment and lymph node metastasis (p = 0.0076). BRCA mutation positive correlated significantly with a high histological grade (p = 0.0243) of tumour.
Conclusion: Breast cancer in women aged ≤30 years more frequently presents as a palpable mass with malignant imaging features and a high histological grade. The imaging and clinical features are significantly associated with prognostic factors of breast cancer in this patient population.
Author affiliation(s):
JH Lee, E Cho: Department of Radiology, Dong-A University College of Medicine, Republic of Korea
CM Kuzmiak: Department of Radiology, University of North Carolina School of Medicine, United States
YM Park: Department of Busan Paik Hospital, Inje University College of Medicine, Republic of Korea
中文摘要
30歲及以下女性乳癌的典型特徵
JH Lee、CM Kuzmiak、E Cho、YM Park
目的：確定和描述30歲或以下女性乳癌患者的影像學、臨床病理學和生物學特徵，並將影像學特徵與乳癌的臨床和分子預後因素聯繫起來。
方法：納入47名確診乳癌的30歲或以下女性患者，回顧分析檢視患者的門診就診、放射學和病理報告。我們使用Fisher精確檢驗分析特徵和結果之間的關聯。
結果：最常見的超聲波特徵是具有可疑惡性腫瘤特徵的腫塊。當中屬乳腺影像學報告及數據系統（BI-RADS）第4類佔82.2%（37/45），第5類佔17.8%（8/45）。在浸潤性腫瘤中，69.0%（29/42）屬高組織學級別，61.4%（27/44）的雌激素受體呈陽性，56.8%（25/44）的黃體素受體呈陽性，25.6%（11 / 43）的人類表皮生長因子受體二型呈陽性。乳房X光造影檢查的腫瘤邊緣與BRCA突變（p = 0.0217）、超聲波掃描的腫瘤特徵包括其邊緣、回音模式和腫瘤後部特徵與激素受體狀態（p = 0.0117-0.0467），以及BI-RADS評估與淋巴結轉移（p = 0.0076）均顯著相關。BRCA突變呈陽性與腫瘤的高組織學級別顯著相關（p = 0.0243）。
結論：30歲或以下的女性乳癌患者，呈現可觸及的腫塊，具有惡性影像學特徵和較高的組織學分級。成像和臨床特徵與患者人群的乳癌預後因素顯著相關。