Management of Chordoma in a Tertiary Hospital in Hong Kong
JCH Chan, AKC Leung, ST Fong, HM Chiu, RKC Ngan
Hong Kong J Radiol 2017;20:28-33
DOI: 10.12809/hkjr1716854
Objectives: To report the clinical characteristics, treatment, and outcome of 25 patients with chordoma.
Methods: The medical records of 25 patients with chordoma treated in a regional hospital in Hong Kong between January 2000 and June 2016 were retrospectively reviewed. Their clinical, pathological, treatment, and survival data were collected and analysed.
Results: Of the 25 patients, 14 had skull base and 11 had sacral tumours; 78.6% and 100% were conventional chordoma, respectively. Their median ages were 41 and 64 years, respectively. In the skull base cohort, all 14 patients underwent surgery but none achieved R0 resection, and 13 received adjuvant radiotherapy. In the sacral cohort, eight of 11 patients underwent surgery and three of them achieved R0 resection. Four patients received postoperative radiotherapy. The 5-year local control rates for skull base and sacral chordoma were 29.6% and 17.9%, respectively, with a median time to progression of 42 (range, 8-68) and 33 (range, 4-76) months, respectively. The 5-year overall survival rates were 64.3% and 72.2%, respectively.
Conclusion: Treatment outcome of chordoma patients in our hospital was suboptimal. Strategies to improve outcome should be explored.
Authors’ affiliations:
JCH Chan, AKC Leung, RKC Ngan: Department of Clinical Oncology, Queen Elizabeth Hospital, Jordan, Hong Kong
ST Fong: Department of Orthopaedics and Traumatology, Queen Elizabeth Hospital, Jordan, Hong Kong
HM Chiu: Department of Neurosurgery, Queen Elizabeth
Hospital, Jordan, Hong Kong
中文摘要
香港一間綜合醫院的脊索瘤治療經驗
陳俊軒、梁國璋、方善德、趙鶴鳴、顏繼昌
目的：報告25例脊索瘤患者的臨床特徵、治療和結果。
方法：回顧性分析2000年1月至2016年6月在本院的25例脊索瘤患者的病歷資料，並分析其臨床、病理、治療和存活數據。
結果：25例患者中，14例為顱底腫瘤而11例為骶骨腫瘤；78.6%和100%的顱底和骶骨腫瘤分別是常規脊索瘤。患者的中位年齡分別為41歲和64歲。在顱底瘤組中，所有14例患者接受手術但沒有達至R0切除，其中13例接受輔助放療。在骶骨瘤組中，11名患者中的8名接受手術，其中3名達至R0切除。4名患者接受術後放療。5年局部控制率分別為29.6%和17.9%。瘤擴散的中位時間分別為42（範圍：8-68）和33（範圍：4-76）個月。5年總存活率分別為64.3%和72.2%。
結論：本院治療脊索瘤的效果不理想。應該探索改善療效的策略。