Radioembolisation of Hepatocellular Carcinoma and Liver Metastases: Imaging Findings Using 90Y Positron Emission Tomography/Computed Tomography and Bremsstrahlung Single Photon Emission Computed Tomography/Computed Tomography

Full Article

WH Ma, M Law, WY Ho, KK Wong, S Ng, HY Lau, WK Tso

Hong Kong J Radiol 2014;17:140-4

DOI: 10.12809/hkjr1413199

Radioembolisation with Yttrium-90 (⁹⁰Y)–labelled microspheres administered via the hepatic artery is currently used to treat primary and metastatic non-resectable liver tumours. ⁹⁰Y is a pure beta-particle emitter and its energetic beta particle has a range of about 4 mm in soft tissue, making it well suited for treatment of bulky tumours. Bremsstrahlung single photon emission computed tomography/computed tomography (SPECT/CT) is commonly performed to assess the biodistribution of ⁹⁰Y-labelled microspheres post-radioembolisation. Because ⁹⁰Y emits positrons in a small percentage of its decays, ⁹⁰Y positron emission tomography/computed tomography (PET/CT) has recently been used for this purpose, yielding higher-resolution visualisation of the distribution of the microspheres. This pictorial review presents, compares, and contrasts Bremsstrahlung SPECT/CT and PET/CT images post-radioembolisation in four patients treated with ⁹⁰Y-microspheres.

中文摘要

肝癌和肝轉移瘤的放療性栓塞：用⁹⁰Y正電子發射斷層掃描/CT和軔致輻射單光子發射電腦斷層/CT顯像結果

馬慧嫻、羅惠明、何偉然、黃廣權、吳楚儀、劉顯宇、曹偉權

經肝動脈內注入釔（⁹⁰Y）微球放療性栓塞目前用於治療無法手術切除的原發性和轉移性肝癌。⁹⁰Y是一個純β粒子發射器，其高能β粒子的射程在軟組織中約有4 mm，所以適合用於治療大體積的腫瘤。軔致輻射單光子發射電腦斷層/電腦斷層掃描（SPECT/CT）常用於評估放療栓塞後⁹⁰Y微球的分佈。由於⁹⁰Y衰變過程中會釋放少量正電子，⁹⁰Y正電子發射斷層掃描/電腦斷層掃描（PET/CT）最近應用於臨床以得出更高分辨率的微球分佈。本文比較分析四名接受⁹⁰Y微球放療性栓塞後病人的致輻射SPECT/CT和PET/CT的圖像結果。