Chronic Lymphocytic Leukaemia and Multiple Myeloma
N Pulenzas, A Porwit, KJ Craddock, N Thavarajah, B Lechner, L Holden, N Lauzon, E Chow
Hong Kong J Radiol 2014;17:135-9
DOI: 10.12809/hkjr1313177
Association of chronic lymphocytic leukaemia and multiple myeloma in the same individual is rare. These malignancies may be related through a common clonal origin, or exist as separate malignancies from different clones. Multiple myeloma may exist simultaneously with chronic lymphocytic leukaemia, or be diagnosed several months after chronic lymphocytic leukaemia. Common symptoms experienced in these rare cases are generally a combination of clinical features typically seen in chronic lymphocytic leukaemia and multiple myeloma separately. This report describes a 76-year-old man with coexisting chronic lymphocytic leukaemia and multiple myeloma. Diagnosis of chronic lymphocytic leukaemia preceded the diagnosis of multiple myeloma by approximately 4 years, and multiple myeloma presented with translocation t(11;14) that was not found in chronic lymphocytic leukaemia cells.
中文摘要
慢性淋巴細胞白血病和多發性骨髓瘤
N Pulenzas, A Porwit, KJ Craddock, N Thavarajah, B Lechner, L Holden, N Lauzon, E Chow
慢性淋巴細胞白血病和多發性骨髓瘤很少會發生於同一個病例。這些惡性腫瘤可能經同源性克隆聯合發生，或作為源自不同克隆的惡性腫瘤而各自存在。多發性骨髓瘤可能和慢性淋巴細胞性白血病同時存在，也可能於慢性淋巴細胞白血病被診斷數個月後才發現。這些罕見病例的共同症狀為慢性淋巴細胞白血病及多發性骨髓瘤各自典型臨床特徵的綜合。本文報告一名同時患有這兩種病症的76歲男子，在發現多發性骨髓瘤的大約四年前，已診斷患有慢性淋巴細胞白血病。其多發性骨髓瘤帶有易位t（11;14）未有在慢性淋巴細胞白血病細胞中發現。