Radiological Zebra Lines Correspond to Bisphosphonate Administration in Children with Osteogenesis Imperfecta
HN Wong, T Nozaki, M Matsusako, I Kusakawa
Hong Kong J Radiol 2013;16:219-23
DOI: 10.12809/hkjr1312135
Bisphosphonates are widely used in the treatment of osteogenesis imperfecta due to their action of limiting bone resorption by inhibiting osteoclast activity. Sclerotic bands, which are known as metaphyseal lines, are observed in the metaphysis of the long bones in paediatric patients treated with bisphosphonates for osteogenesis imperfecta before closure of the growth plate, and the number of metaphyseal lines corresponds to the number of treatment cycles. Metaphyseal lines are sometimes called ‘radiological zebra lines’. This report of two paediatric patients with osteogenesis imperfecta receiving cyclic bisphosphonates describes the pattern of radiological zebra lines corresponding to bisphosphonate administration. The distances between the lines show an increasing interval towards the diaphysis in growing bones.
中文摘要
兒童成骨不全症患者雙磷酸鹽類藥物治療相應的放射性斑馬線現象
王馨藝、T Nozaki、M Matsusako、I Kusakawa
雙膦酸鹽能抑制破骨細胞的活性從而限制骨吸收，所以被廣泛用於治療成骨不全症。硬化帶又稱為幹骺端線，可在接受雙膦酸鹽治療的成骨不全症兒童患者的長骨骺板閉合前觀察到；其數目與療程數目相對應。幹骺端線有時也被稱為「放射性斑馬線」。本文報告兩名接受週期性雙膦酸鹽治療的兒童成骨不全症患者，描述相應放射性斑馬線的形態。對於生長期的骨幹，斑馬線之間的間距會越來越大。