Prevalence and Factors Associated with Brown Adipose Tissue Detected by 18F-fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in Southern Chinese
TM Leung, KSL Lam, CY Wong, PL Khong
Hong Kong J Radiol 2013;16:183-90
DOI: 10.12809/hkjr1313182
Objectives: This study aimed to evaluate the prevalence of brown adipose tissue, as detected by fluorine 18-fluorodeoxyglucose positron emission tomography combined with computed tomography (18F-FDG PETCT), in a Southern Chinese population. It also set out to determine associated factors with brown adipose tissue, and particularly its relationship with being overweight and having other metabolic disorders such as diabetes mellitus.
Methods: We analysed 1765 consecutive 18F-FDG PET-CT scans of 1442 Chinese subjects for the presence of brown adipose tissue. Comparison of variables in subjects with positive and negative brown adipose tissue scans was performed using Student’s t test. The predictors of observed brown adipose tissue were analysed by multiple logistic regressions. Any p < 0.05 was considered statistically significant.
Results: Brown adipose tissue was detected in 66 (4.6%) out of 1442 subjects. There were significant differences in age, gender, body mass index, blood glucose levels, and history of diabetes in subjects positive and negative for brown adipose tissue. In the multiple logistic regression test, age and mean monthly temperatures were both independent predictors of the presence of brown adipose tissue (p ≤ 0.001), which was itself a significant independent predictor of being overweight (p = 0.001).
Conclusions: Age was the most important factor associated with the prevalence of brown adipose tissue in humans. Lower outdoor temperatures in winter can increase the prevalence of brown adipose tissue, even in subtropical climates. There was also an association of brown adipose tissue with being overweight and having higher blood sugar levels, supporting the notion that brown adipose tissue may be a potential therapeutic target for obesity and diabetes.
中文摘要
利用18F-FDG PET/ CT檢測中國南方人口褐色脂肪組織的流行率及相關因素
梁紫微、林小玲、王晴兒、孔碧蘭
目的：利用18F-氟代脫氧葡萄糖正電子成像術—電腦斷層掃描（18F-FDG PET-CT）評估中國南方人口中褐色脂肪組織的流行率，並確定與褐色脂肪組織相關的因素，特別是與超重和其他代謝性疾病（如糖尿病）的關係。
方法：分析1442名中國人的1765次18F-FDG PET-CT掃描有褐色脂肪組織的流行率。使用 t 檢驗比較分析褐色脂肪組織陽性與陰性兩組受試對象的變量。並用多元logistic回歸分析找出褐色脂肪組織的預測因子。所有p < 0.05的差異均具統計學意義。
結果：1442例中，66個（4.6%）有褐色脂肪組織。褐色脂肪組織陽性與陰性兩組受試對象在年齡、性別、身體質量指數、血糖水平和糖尿病史均有顯著差異。多元logistic回歸分析顯示，年齡和每月平均溫度是褐色脂肪組織的獨立預測因子（p ≤ 0.001），而褐色脂肪組織本身就是超重的一個重要獨立預測因子（p = 0.001）。
結論：年齡是發生褐色脂肪組織的最重要的相關因素。在冬季，即使是在亞熱帶氣候，較低的室外溫度可以增加褐色脂肪組織的流行率。褐色脂肪組織與超重和較高的血糖水平相關，支持褐色脂肪組織可能是肥胖症和糖尿病的一個潛在治療目標的觀點。