Primary Cutaneous Gamma-delta T-cell Lymphoma: Predominant Subcutaneous Uptake Detected by 18F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomographic Scan in a Rapidly Deteriorating Patient

B Lo, CM Lok, KM Kwok, WP Chu, WS Mak, NY Sin

Hong Kong J Radiol 2011;14:108-12

Primary cutaneous gamma-delta T-cell lymphoma is a rare subtype of primary cutaneous peripheral T-cell lymphoma. In the latest World Health Organization / European Organisation for Research and Treatment of Cancer classification and World Health Organization classification (4th edition, 2008), the entity previously called “subcutaneous panniculitis-like T-cell lymphoma with gamma-delta T-cell phenotype” has been reclassified as a form of primary cutaneous gamma-delta T-cell lymphoma. Most literature reported low positive rates of 18F-fluorodeoxyglucose positron emission tomography/computed tomographic scans in patients with cutaneous lesions. To our knowledge, the pattern of diffuse predominant subcutaneous uptake in cutaneous gamma-delta T-cell lymphoma using positron emission tomography/computed tomographic scans has rarely been described. In this report, we describe the clinical presentation, pathological findings, and the predominant subcutaneous uptake pattern revealed by positron emission tomography/computed tomographic scanning in a patient with a subcutaneous fat biopsy proven peripheral T-cell lymphoma of the gamma-delta phenotype.

中文摘要

原發性皮膚γδT細胞淋巴瘤：18F-氟脫氧葡萄糖正電子電腦斷層顯像 （18F-FDG PET/CT）於一迅速惡化病例中呈顯著皮下攝取

羅彪、駱昭明、郭勁明、朱惠邦、麥詠詩、單雅怡

原發性皮膚γδT細胞淋巴瘤屬於原發性皮膚外周T細胞淋巴瘤的一個罕見類型。根據世界衛生組織 （WHO）／歐洲癌腫研究治療機構（EORTC）的最新分類表（2008年第四版），之前的「皮下似脂 膜炎γδT細胞淋巴瘤T細胞表型」經已被重新分類，成為原發性皮膚γδT細胞淋巴瘤的其中一種。大 多數文獻記載著18F-FDG PET/CT對於皮膚病灶患者的陽性檢測率偏低。據我們所知，文獻少有記載 18F-FDG PET/CT檢出皮膚γδT細胞淋巴瘤瀰漫性皮下FDG攝取的顯著表現。本文描述一名經活檢證實患有皮下似脂膜炎γδT細胞淋巴瘤T細胞表型的病人，其臨床症狀、病理學結果及18F-FDG PET/CT顯 示皮下FDG攝取的模式。