Semi-quantification of Hepatic Steatosis in Patients with Chronic Liver Disease Using the Multiecho Two-Point Dixon Technique with Histopathology as the Reference Standard
P Korpraphong, K Somsap, P Saiviroonporn, A Pongpaibul, P Charatcharoenwitthaya
Hong Kong J Radiol 2015;18:4-10
DOI: 10.12809/hkjr1414261
Objectives: To determine the utility of the multiecho two-point Dixon technique in the semi-quantification of hepatic fat in patients with chronic liver disease and compare these results with the histopathology outcomes.
Methods: In a retrospective study, patients with chronic liver disease who underwent both magnetic resonance imaging and liver biopsy on the same day between June 2012 and May 2013 were included. The hepatic fat fraction was calculated from water and fat images and reported by their mean. Liver specimens were reviewed by a hepatopathologist blinded to the radiological data.
Results: Among 21 patients with histological evaluation, steatosis was present in 15 patients and was of grade 1 in nine patients, grade 2 in four patients, and grade 3 in two patients. No hepatic steatosis (grade 0) was found in six patients. The median (range) of the hepatic fat fraction of patients with steatosis grades 0, 1, 2, and 3 were 2.4 (1.9-3.3), 6.4 (2.7-10.6), 19 (14.9-26.4), and 45.7 (20.1-71.3), respectively (p < 0.001).
Conclusion: Semi-quantification of hepatic steatosis using the multiecho two-point Dixon technique is a non-invasive method that provides reasonably accurate data about the severity of fat deposition in a range of liver diseases. The implementation of this sequence into the routine hepatic steatosis magnetic resonance imaging protocol could be of great benefit.
中文摘要
多迴波兩點Dixon法聯合組織病理學作為慢性肝病患者中肝脂肪變性半定量檢測的參考標準
P Korpraphong, K Somsap, P Saiviroonporn, A Pongpaibul, P Charatcharoenwitthaya
目的：評估多迴波兩點Dixon法為慢性肝病患者作肝脂肪變性半定量檢測的效用，並與組織病理學的結果作比較。
方法：把2012年6月至2013年5月期間於同一天內接受磁共振成像和肝活檢的慢性肝病患者納入本回顧研究。從水和脂肪圖像計算出肝臟脂肪分數，並報告其平均值。肝臟樣本則由不知道影像數據的肝臟病理學醫生審查。
結果：21名已進行病理學評估的病人中，脂肪肝有15例，其中9例屬一級，4例屬二級，2例屬三級。其餘6例並無脂肪肝（零級）。患者的肝臟脂肪分數的中位數（範圍）為：零級2.4（1.9-3.3），一級6.4（2.7-10.6），二級19（14.9-26.4），三級45.7（20.1- 71.3）；p < 0.001。
結論：使用多迴波兩點Dixon法為肝脂肪變性作半定量檢測是一種非侵入性的方法，能為提供一系列肝病中脂肪沉積嚴重度的合理而準確的數據。把該序列納入常規脂肪肝磁共振成像方案大有裨益。