Localised Ureteric Amyloidosis Mimicking Urothelial Tumour
VKP Fung, MF Wong, WK Kan, WS Lau, CK Tai
Hong Kong J Radiol 2014;17:129-34
DOI: 10.12809/hkjr1413192
Amyloidosis is a pathological process characterised by extracellular deposition of fibrillar protein. Systemic amyloidosis with multiple organ involvement is more common than localised amyloidosis. Localised amyloid deposition in the urinary tract is uncommon and isolated involvement of the ureter and renal pelvis is a rare presentation of this uncommon disease. Primary localised amyloidosis of the renal pelvis and ureter can closely resemble malignancy in its presentation, ureteroscopic appearance, and imaging features. This report is of two patients with primary localised amyloidosis involving the renal pelvis and ureter. Both patients first presented with haematuria with loin pain and urothelial tumour was suspected. Diagnosis was only made by histological analysis. In this article, important aspects of the clinical and imaging findings are discussed and the literature is reviewed.
中文摘要
類似泌尿道上皮腫瘤的輸尿管局限性澱粉樣變性
馮啟邦、黃文鳳、簡偉權、劉詠詩、戴志健
澱粉樣變性是一種病理過程，特徵為纖維蛋白在細胞外沉積。多器官受累的系統性澱粉樣變性較局限性澱粉樣變性常見。泌尿道的局限性澱粉樣蛋白沉積很少見，輸尿管和腎盂孤立受累更是這種病的罕見病徵。腎盂和輸尿管的原發局限性澱粉樣變性的症狀、輸尿管鏡表現和影像學特徵非常類似惡性腫瘤。本文報告兩個累及腎盂和輸尿管的原發局限性澱粉樣變性的病例。兩名患者病發時出現血尿與腰痛，起初懷疑是泌尿道上皮腫瘤。診斷只能靠組織學分析。本文探討澱粉樣變性關鍵性的臨床和影像學表現並作文獻回顧。